Lifetime Alcohol Exposure and Breast Cancer Risk
Abstract
This case-control study examines breast cancer risk in relation to lifetime alcohol consumption. Subjects will be 1120 pre-and post-menopausal women, age 35-79, from Erie and Niagara counties in New York State, with incident, pathologically confirmed breast cancer. A total of 2275 controls will be interviewed; controls are randomly selected and frequency matched to cases on age, race and county of residence. Participants complete a computerized interview, which focuses on in-depth lifetime alcohol consumption history. Potential confounding factors are also assessed. A specimen bank is used to store biological samples for future research of serum and urinary markers of hormones, hormone metabolites, vitamins, genetic polymorphisms and blood levels of antioxidants and oxidative stress. This study provides an important opportunity for an efficient examination of alcohol and other risk factors, particularly genetic variability, in relation to breast cancer risk, with potential for clarification of a significant public health problem. Since the inception of the study, 971 breast cancer cases and 2,048 controls have been interviewed and blood samples stored for 795 cases and 1,890 controls. Data collection is still underway, therefore there are no conclusions to report at this time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA387962
Entities
People
- Jo L Freudenheim
Organizations
- University at Buffalo