Soy, Probiotics, and Breast Cancer Prevention
Abstract
The purpose of this study is to investigate the effects of soy and probiotic consumption on estrogen and phytoestrogen metabolism. The methods include in vitro studies to determine the intestinal microflora responsible for phytoestrogen metablism, and a human feeding study in which 18 postmenopausal breast cancer survivors and 18 controls consume four different dietary supplements for six weeks each. The supplements are: 1) soy powder; 2) soy powder + probiotic; 3) milk power; 4) milk powder plus probiotic. Urine is collected for three days before the study begins and for three days at the end of each diet period, for evaluation of urinary estrogen and phytoestrogen metabolites. Food records are collected on the same days as the urines. Feces are collected before the study begins and at the end of each diet period, for evaluation of intestinal microflora profiles. At this point, in vitro studies have been completed. The results suggest that cell culture is not a good model for human intestinal metabolism. All subjects have been recruited into the human feeding study, urines have been collected and processed and fecal samples have been analyzed. Ten subjects have completed the study and all subjects will be done by June, 2001.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA387983
Entities
People
- Mindy S. Kurzer
Organizations
- University of Minnesota