A New Invasion and Metastasis Molecule, Tiaml and Its Interaction With the Cytoskeleton Are Involved in Human Breast Cancer Progression
Abstract
Members of the Rho subclass of the ras superfamily SMALL MOLECULAR WEIGHT GTPases, (e.g. RhoA, Raci and Cdc42) are known to be associated with changes in the membrane-linked cytoskeleton (Ridley and Hall, 1992; Hall, 1998). For example, activation ofRhoA, Raci and Cdc42 have been shown to produce specific structural changes in the plasma membrane-cytoskeleton associated with membrane ruffling, lamellipodia, filopodia, and stress fiber formation (Ridley and Hall, 1992; Hall, 1998). The coordinated activation of these GTPases is thought to be a possible mechanism underlying cell motility, an obvious prerequisite for metastasis (Dickson and Lippman, 1995; Jiang et al., 1994; Lauffenburger and Horwitz, 1996).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA387990
Entities
People
- Lilly Y. Bourguignon
Organizations
- University of Miami