Simulants for Transition States
Abstract
Catalytic antibodies are proteins that catalyze chemical reactions by binding to the transition state and lowering the energy of activation. Transition state analogs are stable compounds that mimic the geometry and electronic structure of the transition structure. These haptens are conjugated to proteins and used to elicit the desired immunoglobulins. Catalytic antibodies have been used to accelerate hydrolysis and ammonolysis reactions, cis-trans isomerizations, Diels-Alder reactions, and to alter the product ratios for cyclization reactions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2001
- Accession Number
- ADA388449
Entities
People
- William E. White