Retinoic Acid Receptors in Metastatic Prostate Cancer

Abstract

This project is a study of the potential role of retinoic acid receptor in the metastasis of prostate cancer. Initial studies identified the RXR-alpha expression to be highly correlated with retinoid sensitivity. In addition, clinical samples showed a trend towards a decreased expression in metastatic cells compared to the primary tumor cells. To determine the function of the retinoid receptor RXR-alpha, an adenovirus transducing RXR-alpha was created and tested in two ways. Prostate cancer cell lines were created to over express the gene. These RXR-alpha transduced cells were showed no change in the sensitivity to retinoids and the metastatic ability when used in a nude mouse model of experimental metastasis, a technique that was also newly developed in this study.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1999
Accession Number
ADA388557

Entities

People

  • Kenichi Takeshita

Organizations

  • NYU Langone Health

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acids
  • Anatomy
  • Animals
  • Biological Sciences
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Laboratory Animals
  • Materials
  • Neoplasms
  • New York
  • Prostate
  • Prostate Cancer
  • Recombinant Dna
  • Retinoic Acids

Readers

  • Oncology (Cancer Research).