Isolation of Breast Tumor Supressor Genes from Chronosome 11p

Abstract

We have previously shown that chromosome 11p15.5 exhibits loss of heterozygosity (LOH) in ^60% of breast tumors, and that there is a significant correlation between 11p LOH, lymphatic invasion and aggressive metastatic disease. Our data suggests that chromosome 11p15.5 harbors a metastasis suppressor gene. An intriguing candidate gene that we have mapped to the metastasis suppressor locus on chromosome 11p15.5 is Integrin-linked kinase (ILK). ILK is a newly identified ankyrin-repeat containing serine/threonine kinase that binds to the cytoplasmic domains of both 131 and the 133 integrins.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2000
Accession Number
ADA388558

Entities

People

  • Pratima Karnik

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chromosomes
  • Diseases And Disorders
  • Genetic Structures
  • Genetics
  • Kidney Diseases
  • Mammary Glands
  • Metastasis
  • Neoplasms
  • Sarcoma

Readers

  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.