Epitope Specific T Cell Immunity to Breast Cancer

Abstract

Studies during the ongoing grant period demonstrated that: (1) the CTL epitope E75 is partial agonist for activation of CTL effector function. It frequently activates IFN-gamma secretion, but infrequently cytolysis. (2) Enhancement of E75 immunogenicity can be achieved by methylene (CH2)-extension at positions in the peptide determined by computer assisted modeling to point upwards and sideways (Alanine position 7). In addition enhanced survival and maintenance of cytolytic activity by E75 can be achieved by priming with the helper peptide G89 (HER-2:776-789) followed by stimulation with CH2-extended E75 (with 3CH2) on the linear side chain of Ala).

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2000
Accession Number
ADA388572

Entities

People

  • Constantin Ioannides

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Antigens
  • Biological Factors
  • Blood
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Genetics
  • Immunogenicity
  • Immunomodulation
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Peptides
  • Proteins
  • Vaccines

Readers

  • Immunology
  • Systems Analysis and Design