Structure of the Estrogen Receptor Dimerization Domain Bound to an Antiestrogenic Phosphotyrosyl Peptide

Abstract

Estrogens are one of the major agents responsible for the development of breast cancer disease. The effects of estrogens are mediated by estrogen receptor (ER) alpha and beta. The ER interacts with specific DNA sequences (EREs) of estrogen responsive genes and modulates gene transcription. The biochemical and physiological features of the newly discovered ER beta remains largely unknown. Estrogen responsive genes contain various imperfect EREs that deviate by one or more nucleotides from the consensus ERE. Since the nature of the ERE determines the transcriptional strength of ER alpha, differences in the binding affinity among EREs could also provide the receptors a way to display distinct gene induction properties.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2000
Accession Number
ADA388577

Entities

People

  • Ping Yi

Organizations

  • University of Rochester

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Estrogens
  • Genetic Structures
  • Hormones
  • Hydroxyl Radical
  • Mammary Glands
  • Nucleotides
  • Polymerase Chain Reaction
  • Proteins
  • Reproductive System
  • Sequences
  • Sex Glands
  • Urogenital System

Readers

  • Molecular Biology and Genetics
  • Regression Analysis.