Estrogen Receptor Gene Polymorphisms and Breast Cancer Risk
Abstract
Purpose: to test the hypothesis that individual variation in the sensitivity to estrogens whether from endogenous or exogenous sources, affects woman's risk of breast cancer. Scope: to test if the variability in responses to estrogens in women may be determined by a functionally significant variation in the estrogen receptor alpha (ER) though which estrogens exert biologic effects. The ER polymorphism under study are: Xba-I, Pvu II and microsattelite polymorphism. In an exploratory analysis we will study the interaction between the Xba I, Pvu II and microsatellite ER polymorphism and estrogen-related risk factors for breast cancer such as reproductive history and menopausal hormone use. Major findings: not yet available (biological sample collection and laboratory analysis still ongoing. Up-to-date report of the progress in terms of results and significance: no results are yet available - we are still collecting biological samples, extracting DNA from the biological materials (leukocytes and pathological slides) and processing the laboratory analysis. These activities are following the time schedule as stated in the Proposal to the Army. We expect to have preliminary results by the spring of year 2001.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2000
- Accession Number
- ADA388663
Entities
People
- Hans-olov G. Adami
- Landegran
Organizations
- Uppsala University