Cell Migration as a Therapeutic Target in Malignant Breast Cancer
Abstract
The object of this project is to develop a high-throughput method for screening potential inhibitors of breast cancer cell haptotaxis and chemotaxis, and to apply this method to identify signaling events mediating constitutive migration of malignant breast cells. The pathways that control these signaling events may be targets for development of new classes of anti-tumor drugs. The significant advances made during the second year of the project include the identification of three molecules that are involved in integrin-mediated cell signaling and migration (RACK 1, Focal Adhesion Kinase, and Ca+2), the development of a model system for examining integrin- specific signaling in breast cells adhering to laminin-1, and the identification of perilly1 alcohol as a non-cytotoxic inhibitor of breast cell migration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2000
- Accession Number
- ADA388762
Entities
People
- George E. Plopper Jr.
Organizations
- University of Nevada, Las Vegas