The Identification of Novel Ligands for Cell Surface Receptors
Abstract
A general problem in metazoan biology is the identification of the specific ligands for transmembrane receptors. One goal of the original proposal was to selectively modify the physiology of the budding yeast Saccharomyces cerevisiae to speed the identification and study of ligand/receptor interactions - in particular that of erB2 given its involvement in breast cancer. Significant progress was made on development of a system that allows a rapid readout for interaction of a receptor with its corresponding ligand. A second approach involves a novel search for small interacting peptide aptamers that could be used as ligand mimics or inhibitors. Peptide aptamer libraries have been characterized and in doing so, a novel peptide effector of the cell cycle regulator Cdk4 was characterized.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA388869
Entities
People
- Pamela Silver
Organizations
- Dana–Farber Cancer Institute