Mechanism of Action of Substituted Indanones in Multidrug Resistant Breast Cancer
Abstract
Mechanism of Action of Substituted Indanones in Multidrug Resistant Breast Cancer Our laboratory has recently synthesized a series of novel substituted indanones that are selectively toxic to multidrug resistant cancer cells, including breast cancer cell lines. In this application we proposed to characterize the mechanism of action of indanocine and to assess the in vivo anti-tumor activity of indanocine. During the first year we: - published the first report on the biological activity of indanocine (J Natl Cancer Inst 2000, 92:217-224) - generated an indanocine-resistant stable cell line - synthesized a water-soluble analog of indanocine (indanocine-phosphate) - tested the anti-angiogenic activity of indanocine in in vivo animal models - demonstrated the selective activity of indanocine against primary chronic lymphocytic leukemia cells The results shown in this annual summary demonstrate that indanocine is a very promising new anti-cancer agent that we hope will be soon tested in clinical trials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA388886
Entities
People
- Lorenzo Leoni
Organizations
- University of California, San Diego