Target Antigens for Breast Cancer Vaccines
Abstract
The prospects for development of well defined tumor vaccines has received great impetus from the demonstration that human melanoma express common antigens recognized by cytotoxic T cells (CTL). Although significant problems related to antigen delivery and immune stimulation remain to be resolved, the availability of molecularly defined breast tumor antigens would be a major step towards development of a vaccine for breast cancer. The most successful approaches to identify antigens uniquely expressed in tumor cells employ tumor-specific cytotoxic T cells to screen a library of gene products expressed in the tumor. We have developed a novel technology for this purpose that is far more efficient and sensitive than the available alternatives. This technology is being coupled with some novel methods to generate breast tumor-specific T cells for analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADA388914
Entities
People
- Ricardo Cibotti