Adhesive Mechanisms in Breast Cancer Metastasis
Abstract
The goal of this project is to understand adhesive mechanisms in breast cancer metastasis because this is the primary cause of death. Breast cancer metastasis to bone, lungs, liver and brain involves the blood stream and requires tumor cell arrest within the vasculature. In leukocytes and platelets, arrest within the vasculature depends on integrin activation. We found that breast cancer cells can express integrin alpha v beta 3 in an activated or a non-activated state. Only activated alpha v beta 3 supported breast cancer cell arrest during blood flow. The metastatic activity of breast cancer cells was strongly increased when alpha v beta 3 was activated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA388954
Entities
People
- Brunhilde Felding-habermann
Organizations
- Scripps Research