Characterization of a B-Catenin-Associated Kinase

Abstract

In the past 12 months we investigated the ability of IKK to regulate beta-catenin signaling activity. We found that IKK exists in a complex with beta-catenin and that expression of either IKK(alpha) or IKK(beta) can decrease Beta-catenin signaling. However, only a dominant negative (DN) IKK(alpha) mutant increased beta-catenin signaling as well as protein levels. In addition, DN IKK(alpha), but not DN IKK(beta), inhibited the ability of APC to decrease beta-catenin signaling. These results suggest that the IKK proteins are involved in beta-catenin regulation.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2000
Accession Number
ADA389329

Entities

People

  • Keith Orford
  • Stephen Byers

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Albumins
  • Apoptosis
  • Biomedical And Dental Materials
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Colon
  • Colon Cancer
  • Epithelial Cells
  • Lymphocytes
  • Neoplasms
  • Neutral Amino Acids
  • Proteins
  • Regulations
  • Stem Cells

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Urban Planning and Geography.