Development of Quantitative Microvascular Breast MRI
Abstract
The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors through the design and preliminary validation of a new form of magnetic resonance imaging (MRI) . The hypothesis is that the spatial distribution of microvasculature around a solid breast lesion is specific for malignancy and can be reliably measured at high resolution by a completely non-invasive, non-contrast-enhanced MRI method. This is being tested by achieving the following: 1. Design/building/testing of ultra-high-strength gradient coils for human breast imaging at 1.5 Tesla (T) and 4T. 2. Design/implementation/testing of MR pulse sequences for selective mapping of microvascular parameters. 3. Correlation of MR-derived microvascular parameters with true microvessel density in a rat model of human breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADA389436
Entities
People
- Brian Rutt