Measuring "Impossible" Intermolecular Cross-Peaks to Improve Selectivity and Specificity in Breast MRI

Abstract

Work in my laboratory at the time of grant submission had shown that intermolecular cross-peaks could be generated in vivo, and that these peaks gave enhanced contrast in rat brain images, including tumor enhancement. Work on this grant in the last period has focused on transitions to human subjects, signal demonstrations of contrast improvement. We have shown that we can take simultaneous, multislice images in humans with acceptable sensitivity at fields as low as 1.5T, the current clinical standard. We have also shown (in phantoms) that we can measure high-resolution localized MR spectra without suspectibility problems, which plague spectroscopic applications in breast tissue. Breast imaging sequences have been implemented on two MRI machines. Pulse sequence optimization for sensitivity and contrast enhancement in breast imaging is underway.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2000
Accession Number
ADA389438

Entities

People

  • Warren S. Warren

Organizations

  • Princeton University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Contrast
  • Data Acquisition
  • Detection
  • Difference Frequency
  • Frequency
  • High Resolution
  • Neoplasms
  • Neuroimaging
  • New Jersey
  • Optimization
  • Sensitivity
  • Sequences
  • Spectra
  • Standards
  • Three Dimensional

Fields of Study

  • Medicine
  • Physics

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