The Role of Id Proteins in Breast Cancer

Abstract

E2A gene products (E47 and E12) are potent transcription factors containing the basic helix-loop-helix (bHLH) domain for DNA binding and dimerization. E2A proteins are thought to control cell growth and differentiation. E2A is also implicated to have a role as a tumor suppressor. E2A function can be inhibited by a group of inhibitors called Id. Thus, overexpression of Id proteins could diminish the function of E2A as a tumor suppressor, and potentially cause breast cancer. To test this hypothesis, we have generated transgenic mice expressing Id-i in mammary epithelial cells, but have not detected any tumor formation. On the other hand, we have found Id-i overexpression in a large fraction of archived human breast cancer samples. The significance of Id-i overexpression in human breast cancer remains to be understood. Furthermore, we have shown that E2A proteins in primary mammary epithelial cells and in the MDA-MB-23 1 breast cancer cell line are degraded through a proteasome mediated pathway. This provides an additional mode of regulation for E2A function in mammary epithelial cells.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2000
Accession Number
ADA389454

Entities

People

  • Xiao H. Sun

Organizations

  • New York Medical College

Tags

DTIC Thesaurus Topics

  • Antisense Elements (Genetics)
  • Biological Sciences
  • Biomedical Research
  • Breast Cancer
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Epithelial Cells
  • Inhibitors
  • Lymphocytes
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • New York
  • Students

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
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