MR Imaging and Gene Therapy of Breast Cancer
Abstract
The main purpose of this Career Development Award is for the P.1. to receive training in the field of Cancer Biology and Virology, so that she can apply her expertise, Magnetic Resonance Imaging, for developing non-invasive techniques to monitor gene therapy induced cellular and vascular changes in breast cancer. In Yr-Ol I have received some training and all ended several courses. In Yr-O2 I have started to expand the experiments by using gene therapy delivered with the adenovirus system to treat animal cancer models, and performing MRI studies to measure the volumetric and vascular changes. A research assistant has been recruited and trained in assisting me performing all aspects of the study, including carrying out the experiments and data analysis. I have also spent some effort in doing extensive literature search to study the recent developments in the application of angiogenesis or anti-angiogenesis therapy using gene delivery systems. The search results have been used in a proposal submitted to NIH, and have successfully obtained funding. In Yr-O3 we will continue to finish the specific aims proposed in the original proposal, with the main effort focusing on the correlation between the MRI measurements of cellular and vascular changes with the underlying biological changes occurring in the tissue, e.g. the change of vessel density.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADA389461
Entities
People
- Min-ying Su
Organizations
- University of California, Irvine