Characterization of an Adhesion Associated Tumor Suppressor in Breast Cancer
Abstract
It is generally understood that cancer is a disease of aberrant signal transduction. In particular, the expression levels or function of receptor tyrosine kinases are frequently elevated in malignant cells. The purpose of our funded project was to identify one particular receptor tyrosine kinase, which was identified using D7 monoclonal antibodies. Our interest in the D7 antigen centered upon its differential expression in benign and malignant cells. Once identified, we sought to overexpress the gene that encodes for the D7 antigen in D7-deficient mammary epithelial cells and test for changes in cell growth and invasiveness.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA389642
Entities
People
- Michael Kinch
Organizations
- Purdue Research Foundation