Examination of the Role of Membrane Type-1 Matrix Metalloproteinase in Breast Cancer Metastasis
Abstract
Recent studies have demonstrated that the production of tissue degrading enzymes (proteinases) by cancer cells lead to cancer dissemination. Matrix metalloproteinases (MMPs) are the major tissue degrading enzymes responsible for metastasis. Among these enzymes, membrane type matrix metalloproteinases are recently described MMP family members. In contrast to other MMPs, MT-MMPs are anchored in the plasma membrane and activate progelatinase A (also named MMP-2) . Since gelatinase A is the MMP most commonly incriminated in breast cancer metastasis, the novel function of MT-MMPs appears important in breast cancer. Because of its central role in cell surface proteolysis, a more complete understanding of the role of MT-MMPs in cancer will expedite progress in therapy of metastasis. To this end, this project has been focused on the role of MTl- MMP in experimental breast cancer invasion and metastasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA389754
Entities
People
- Jian Cao
- Stanley Zucker
Organizations
- State University of New York