Early Detection Based on Angiogenic Growth Factors in Nipple Aspirate Fluid (97breast)
Abstract
The objective of this proposal is to develop new methods of early breast cancer detection by identifying increases in angiogenic growth factor secretion in nipple aspirate fluid (NAF). Specifically, the study is examining FGF-2 (basic fibroblast growth factor) and VEGF (vascular endothelial growth factor), two of the most potent angiogenic molecules whose expression is thought to increase as an early event in breast carcinogenesis. By comparing levels of these growth factors in NAF samples from women from three groups, i.e. those with normal breasts, DCIS (ductal carcinoma in situ), and early invasive breast cancer, we will determine whether increases in either of these molecules heralds the transition to the pre-invasive and/or invasive phenotype. This report covers primarily patient accmal activities during the second year of the project. These activities include finalizing the clinical protocol for identifying, enrolling, and obtaining samples from women in the three groups, and implementing regular enrollment of subjects, and initial analysis of samples.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADA389839
Entities
People
- Bruce J Trock
Organizations
- MedStar Georgetown University Hospital