The Role of the Cell Surface Proteases Meprin A and B in Breast Cancer Progression
Abstract
Progression of cancer cells from a non-invasive, non-metastatic phenotype to an invasive and metastatic phenotype is associated with the expression of a variety of cell surface proteases. Primary among these are the zinc metalloproteases known as matrixins , which include matrix metalloproteases such as collagenases and stromelysins. Matrixins can degrade extracellular matrix proteins, contributing to metastasis and angiogenesis. Another family of zinc metalloproteases are the astacins', which include the extracellular proteases meprin A and B. The expression of a novel form of meprin beta mRNA only in cancer cells, and the secretion of meprin A protein by colon carcinomas has been previously documented. This indicates that these proteases play a role in cancer cell progression. The current project focuses on the expression of meprins A and B in breast cancer cells, and their potential role in tumorigenesis, invasion and metastasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2000
- Accession Number
- ADA389901
Entities
People
- Gail Matters
Organizations
- Pennsylvania State University