Androgen and Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk
Abstract
This project will assess the association between the risk of breast cancer and polymorphisms of the androgen (AR) and vitamin D receptor (VDR) genes among subjects in a recently-completed population-based case-control study in Sweden. A total of 3879 cases and 3527 controls took part, providing questionnaire data regarding use of exogenous hormones and other life style factors. From this study population, breast cancer cases and control women have been randomly selected for genomic DNA analysis. The collection of blood or tissue specimens for DNA has been funded from other sources; this award is for the measurement of the AR and VDR polymorphisms on 300 cases and 300 controls who never used HRT, and a similar number of cases and controls who used HRT for 4 years of more. Information on these polymorphisms will be incorporated into the established subject database, and odds ratios summarizing the associations with breast cancer risk will be computed. In the two first years of the project, the work was organized, and a tracking database for subject recruitment and specimen accrual was built. Recruitment into the molecular epidemiology study is almost complete, and the laboratory analyses will be finished in the forthcoming months. We expect to perform data analysis and reporting of the study results during the next year.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA389999
Entities
People
- John A. Baron
Organizations
- Dartmouth College