A Novel Member of the Insulin-Like Growth Factor Binding Protein Superfamily in Prostate Cancer

Abstract

The insulin-like growth factors (IGFs) are potent mitogens for normal and cancerous prostatic cells. The IGFs are found complexed to IGF binding proteins (IGFBPs) which modulate IGF bioactivity, but also may themselves act in an TGF-independent manner. We have recently characterized a series of IGFBP-related proteins (IGFBP-rPs) which share homology with the IGFBPs in the amino-terminus, bind IGFs with low affinity, and regulate cell growth through both IGF-dependent and IGF-independent actions. This grant is directed at the study of IGFBP-rP2 (also known as connective tissue growth factor) as a regulator of normal and malignant prostatic growth. The specific aims are to: (1) analyze IGFBP-rP2 mRNA and protein expression and distribution in normal and malignant prostatic tissues; (2) determine the transcriptional, translational and post-translational regulation of IGFBP-rP2; and (3) determine the mechanisms by which IGFBP-rP2 regulates prostate growth.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2001
Accession Number
ADA390080

Entities

People

  • Ron G. Rosenfeld

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Blood
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Colon Cancer
  • Connective Tissue
  • Culture Media
  • Enzyme Inhibitors
  • Epithelial Cells
  • Gene Expression
  • Growth Factors
  • Health Services
  • Neoplasms
  • Peptide Growth Factors
  • Prostate Cancer
  • Proteins

Readers

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