Breast Cancer Screening Using Photonic Technology
Abstract
The research performed during the current reporting period included: (a) time-sliced and spectroscopic two-dimensional (2-D) near-infrared transillumination imaging of normal and cancerous in vitro human breast tissue specimens; (b) derivation of analytical solutions of the Boltzmann radiative transport equation; and (c) development of theoretical formalism and computer algorithm for three-dimensional (3-D) inverse image reconstruction method using back-propagating light. Images recorded with earlier temporal slices of transmitted light were found to highlight cancerous tissues while those recorded with later slices accentuated normal fibrous tissues. Initial spectroscopic imaging experiments show that the ratio, R of light intensity transmitted through the cancerous tissue to that through the corresponding normal tissue show a wavelength dependent variation that has the potential to be used as a useful parameter for cancer identification. The analytical solutions of the Boltzmann transport equation enable a more accurate description of the ballistic and snake components of light emerging from a highly-scattering medium than that afforded by the diffusion approximation. Inverse image reconstruction scheme using simulated backscattered light provides fast, noise-resistant 3-D images of objects at various depths up to 2 cm in a tissue- like scattering medium.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2000
- Accession Number
- ADA390088
Entities
People
- Robert Alfano
Organizations
- City University of New York