The Role of NF-kB in Normal and Transformed Mammary Epithelium
Abstract
A knowledge of the molecular signaling pathways which, when perturbed, result in mammary cell transformation would provide vital information in the fight against breast cancer. The NF-kB family of transcription factors are a major component of pathways regulating cell proliferation, differentiation and death. We are attempting to determine their role in the development of normal and transformed mammary epithelium. Our hypothesis is that expression of specific NF-kB factors is necessary for the proper differentiation and maturation of mammary epithelium and that altered expression of kB factors can effect transformation of mammary epithelium. We have created lines of transgenic mice which overexpress a family member suspected to be involved in carcinogenesis (NFkB2) or a dominant inhibitor of NF-kB activity (IkBalpha-DELTAN) in the mammary gland. These murine models are now being analyzed to determine how proliferation, differentiation and death are changed in response to altered kB activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA390684
Entities
People
- Fiona E. Yull
Organizations
- Vanderbilt University Medical Center