Artificial Metallo-Phosphoesterase

Abstract

Our first two US Army contracts (July 1, 90 to June 30, 93 & Mar 15, 94 to Mar 14 97) involved the study of mono and dinuclear metal complexes for hydrolyzing phosphate esters. We have now completed our third US Army contract. Due to my recent move from McGill University to University of Toronto (July 1, 00), the funding period for the third contract was reduced from three to two years (July 1, 98 to June 30, 00). During this period, we continued to study the role of metal ions in phosphate hydrolysis reactions with particular emphasis on understanding the hydrolysis of phosphates with good and poor leaving groups. We also studied the synergistic effect between metal coordination and H-bonding in phosphate hydrolysis. Finally, we have been able to dissect the role of metal ions in hydrolyzing phosphates. Generous funding from ARO for all of the above work is greatly appreciated!

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Document Details

Document Type
Technical Report
Publication Date
May 25, 2001
Accession Number
ADA390869

Entities

People

  • Jik Chin

Organizations

  • McGill University

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DTIC Thesaurus Topics

  • Abstracts
  • Acids
  • Chemistry
  • Classification
  • Contract Administration
  • Contracts
  • Coordination Complexes
  • Hydrogen
  • Hydrogen Bonds
  • Hydrolysis
  • Information Operations
  • Lewis Acids
  • Military Research
  • Organophosphates
  • Security
  • Universities

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