Characterization of CTL Recognized Epitopes on Human Breast Tumors
Abstract
Studies supported by this grant lead to identification of three novel antigens presented by breast cancer cells, which are recognized by cytotoxic T lymphocytes (CTL). These tumor antigens are: (1) HER-2 (HER-2/neu proto-oncologene product), (2) folate binding protein (FBP), folate receptor - alpha, and (3) amino enhancer of split (AES), a transcription factor associated with the Notch complex. These epitopes associated with these antigens were identified in association with HLA-A2. HLA-A2 is expressed in the majority (45-50%) of the North American population. Therefore these epitopes are important for targeting adoptive and vaccine therapies. The ability of peptide mapping these epitopes to activate lymphocytes demonstrated that these epitopes are immunogenic and can be incorporated in vaccines against breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA391396
Entities
People
- Constantin G. Ioannides
Organizations
- The University of Texas MD Anderson Cancer Center