Characterization of Genetic Alterations in Ovarian Cancer
Abstract
Ovarian cancer is a highly lethal malignancy specific to women. We have set up the infrastructure at Mayo for an Ovarian Cancer Research Program utilizing the rich resources of clinical material and linking work from molecular geneticists with that of dedicated clinicians. We are proposing to combine several powerful strategies to clone many of fie genes involved in ovarian cancer development. The first project focuses on identifying genes that are over-expressed or under-expressed during the development of ovarian cancer using subtraction suppression hybridization cDNA libraries and Gene Expression Array Analysis in collaboration with Millennium Predictive Medicine. The second project focuses on the role of gene amplification in familial versus sporadic ovarian cancer. The third project is to characterize two common fragile sites, FRA6F (6q21) and FRA6E (6q26) which are derived from chromosomal regions frequently deleted in ovarian cancer and that also contain genes involved in replication senescence. Thus we have three interactive projects whose overall focus is to identify key genetic targets in the development of ovarian cancer. This Program Project is centered within a larger institutional effort to better understand the biology of the development of ovarian cancer and to devise better strategies for prevention, early detection and treatment of this lethal disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA391417
Entities
People
- David R. Smith