Breast Cancer Biomarkers Based on Nipple and Fine Needle Aspirates
Abstract
Breast cancer is the most common cancer and a leading cause of cancer deaths in women in the United States. The purpose of this project is to identify one or more biomarkers which can be used to identify women at high-risk of developing breast cancer before cancer develops. Prior to undergoing breast surgery, women at increased and normal risk of developing breast cancer will undergo fine needle aspiration (FNA) for determining a series of cytologic, cell cycle and molecular biologic markers of clinical significance for cancer development. These biomarkers include: cytology, DNA index, cell cycle parameters, proliferation index, epidermal growth factor receptor overexpression, p53 and RAS hotspot mutations and hypermethylation of specific gene products (p16, GSTP and E-cadherin). Michael Torosian, M.D. has recently assumed the role of principal investigator of this project and has updated the clinical and scientific aspects of this project. Submission of this project to the IRB at Fox Chase Cancer Center is anticipated within the next 3 months and subject accrual should begin immediately after IRB approval.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2000
- Accession Number
- ADA391957
Entities
People
- Michael Torosian
Organizations
- Fox Chase Cancer Center