Inherited Susceptibility to Breast Cancer in Healthy Women: Mutation in Breast Cancer Genes, Immune Surveillance, and Psychological Distress
Abstract
The purpose of the research supported by this IDEA grant award, is to provide the first critical test of the possibility that variability in the strength of immune surveillance mechanisms against cancer (operationally defined by assessment of natural killer cell activity) may be a factor in determining the penetrance of mutations in breast cancer susceptibility genes. Two possible explanations for variability in NK cell activity are being investigated: 1) stress-induced immune suppression, and 2) inherited deficits in immune surveillance. To date, largely as a result of challenges posed by a change in study site associated with a new academic position for the PI, the study has fallen substantially behind anticipated recruitment levels. As we have husbanded resources, while addressing these challenges, we anticipate making substantial progress in meeting study goals for the next year. We anticipate requesting a no-cost extension of the award, which would further enhance our ability to successfully complete the program of work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA391964
Entities
People
- Dana H Bovbjerg
Organizations
- Icahn School of Medicine at Mount Sinai