Acute Effects of Organophosphorous Compounds on the Ovine Fetus
Abstract
The goal is to achieve a better understanding of the toxicity to the fetus of organophosphorous compounds. In ovine plasma, paraoxon inhibition of maternal acetylcholinesterase was 100-fold below that of the fetus. 2-PAM reduced paraoxon-induced inhibition in maternal plasm by approximately fifty percent but had no effect on inhibition in fetal plasma. Hydrolysis of p-nitrophenyl acetate was similar with plasma from human, baboon (maternal and fetal) and maternal sheep but only one half this rate in fetal sheep. Hydrolysis of procaine was most rapid in human plasma, with baboon plasma (maternal and fetal) 4-5 fold lower. Unexpectedly, neither maternal nor fetal plasma hydrolyzed procaine. Hydrolysis of paraoxon in plasma from maternal or fetal baboon was undetectable. In sheep, maternal plasma rapidly hydrolyzed paraoxon whereas fetal plasma lacks the ability to hydrolyze this compound.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 19, 2001
- Accession Number
- ADA392065
Entities
People
- Manford C. Castle
Organizations
- Eastern Virginia Medical School