The Roles of the Y Chromosome Genes in Prostate Cancer
Abstract
At present, information regarding the contribution of the men-only chromosome, the Y chromosome, to prostate cancer is lacking. The goals of this project are designed to address this question and to identify candidate genes on the Y chromosome involved in prostate cancer. The objectives are: 1) to study the expression of Y chromosome genes in prostate cancer and 2) to evaluate their effects in over-expression in the prostate of transgenic mice. In year 1, we completed the expression survey of all 31 functional genes on this chromosome. Results from this study identified the TSPY gene to potentially play a significant role in prostate cancer development and/or progression. for the next two years of the project, we plan to focus on an expression-function evaluation of TSPY and other Y chromosome genes using transgenic mouse approach, proposed under Objective 2. These studies will provide important information regarding the role of this male-specific chromosome on prostatic oncogenesis and in development of new diagnostic procedures, and/or treatment for this disease. In addition, the generation of transgenic mouse models of prostate cancer will be invaluable in understanding the disease mechanisms, therapeutic strategies and prevention of prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2001
- Accession Number
- ADA392275
Entities
People
- Yun-fai C. Lau
Organizations
- Northern California Institute for Research and Education