An Investigation of the Stoichiometry of Na+ Cotransport with Dopamine in Rat and Human Dopamine Transporters Expressed in Human Embryonic Kidney Cells

Abstract

The neuronal membrane transporter for dopamine (DAT) is a member of the Na+ and Cl dependent family of transporters and concentrates dopamine intracellularly up to 106 fold over extracellular levels. NY is hypothesized to provide the major driving force for this concentrative property. In order to validate the Na+-gradient hypothesis, it must be shown that NY accumulates in stoichiometric amounts along with the substrate.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2001
Accession Number
ADA392279

Entities

People

  • Paul D. Schumacher Iii

Organizations

  • Washington State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Brain
  • Cell Membrane
  • Cells
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Diagrams
  • Drug Abuse
  • Enzyme Kinetics
  • Epithelial Cells
  • Health Services
  • Measurement
  • Membrane Potentials
  • Rodents
  • Schematic Diagrams

Fields of Study

  • Biology

Readers

  • Microbial Pathology
  • Molecular and Cellular Biology
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.