Prostate Cancer Treatment Based on the Suppression of Andiogenesis and Metastasis

Abstract

A polymeric form of fibronectin, superfibronectin (sFN), is a novel non-cytotoxic compound that has impressive anti-metastatic effects in animal experiments. It is thought to act by interfering with adherence and/or migration of tumor cells in the host. Metastases originating from human melanoma, sarcoma and carcinoma cells have been found to be suppressed by sFN. In this stage for the project, we proposed to determine the feasibility of using sFN as an anti- prostate cancer agent by addressing three important issues: 1) demonstration that sFN is effective in preventing the spread of established tumors; 2) lack of detailed studies regarding the toxicity of sFN; and 3) lack of standardization of the sFN polymerization process.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2001
Accession Number
ADA392343

Entities

People

  • Renata Pasqualini

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Biomedical Research
  • Blood
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Endothelial Cells
  • Medical Personnel
  • Metastasis
  • Molecules
  • Neoplasms
  • Peptides
  • Prostate
  • Prostate Cancer
  • Proteins
  • Therapy

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).