Interrelationships of Prenatal and Postnatal Growth, Hormones, Diet and Breast Cancer
Abstract
The purpose of this Career Development Award was to expand Dr. Sanderson's current breast cancer research from the effect of intrauterine exposure to estrogen on breast cancer to the interrelationships of prenatal and postnatal growth, hormones, diet and breast cancer. Based on these interrelationships, we hypothesized that insulin resistance will be positively associated with breast cancer. Further, we hypothesized that genetic susceptibility, and adolescent/adult diet and physical activity will modify the effect of insulin resistance on breast cancer. Specific aims were: (1) to undergo intensive training in cancer biology, and nutritional, molecular and genetic epidemiology, (2) to obtain funding to conduct case-control studies of the insulin resistance-breast cancer relationship, and (3) to obtain fending to conduct a cohort study of the association between prenatal and postnatal growth and infant hormone levels. To date, Dr. Sanderson has audited Pathology of Neoplasia, gained knowledge of analyses of dietary intake and anthropometric measurements, submitted an Idea Award to the Department of Defense to investigate insulin resistance and breast cancer, analyzed data from the Shanghai Breast Cancer Study, and participated in a childhood obesity work group at the University of South Carolina. Dr. Sanderson is transferring this Award to the University of Texas School of Public Health - Brownsville.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2001
- Accession Number
- ADA392347
Entities
People
- Maureen Sanderson
Organizations
- University of South Carolina