Phase I Relation of Genes to Prostate Cancer Occurrence and Aggressiveness
Abstract
We are studying brothers with and without prostate cancer in order to investigate the potential relation between genetic factors and their disease. During the reporting period of this Idea Development Award we have concluded recruitment exceeding our sample size goals (over 1,000 men total recruited). From each of these men we have obtained 30 mls of blood and a risk factor questionnaire. Using these data, and in collaboration with other researchers, we have made four extremely encouraging discoveries with regard to the potential relation of genetic factors to prostate cancer occurrence and aggressiveness. First, using an association approach, we have detected a relation between a variant in the CYP3A4 gene and prostate tumor aggressiveness among African-Americans. Second, in a collaborative linkage analysis, we have undertaken two genome-wide scans that localized candidate regions possibly harboring genes for the development of prostate cancer. Third, we have undertaken a genome-wide linkage analysis of tumor aggressiveness genes, localizing regions that may harbor genes affecting prostate cancer progression. Finally, we have followed up our linkage results with loss of heterozygosity analyses that have substantially narrowed the width of the most promising candidate regions. Our results implicate genes in the development and/or aggressiveness of prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2001
- Accession Number
- ADA392353
Entities
People
- John S. Witte
Organizations
- Case Western Reserve University