Tumor Suppressors and Breast Cancer: Molecular Interaction of Retinoblastoma Protein (Rb) with a New Rb-binding Protein (RIZ)

Abstract

Cancer arises from an accumulation of multiple mutations that may occur in oncogenes, tumor suppressor genes or DNA repair genes. Tumor suppressors control cell cycle and growth and mutations or alterations in these suppressors can be associated with the uncontrolled growth of malignant tumors. In this project, tumor suppressors were studied highlighting a new protein called RlZ. The goal is to use x-ray crystallography to study the molecules. The results will be important to understanding the role of the new regulator protein RlZ in tumorigenesis in breast cancer. This IDEA project focused on the first steps in the process, i.e. production, purification and crystallization of the proteins. Notable progress was made in identifying the PR domain in RlZ that is directly linked to tumor suppression. PR is underexpressed in breast cancer. Feasibility for structural studies of this new protein motif (PR) was established.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2001
Accession Number
ADA392387

Entities

People

  • Kathryn R. Ely

Organizations

  • Sanford Burnham Prebys Medical Discovery Institute

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosomes
  • Crystal Lattices
  • Crystal Structure
  • Crystallization
  • Crystallography
  • Crystals
  • Diffraction
  • Neoplasms
  • Production
  • Retinal Diseases
  • Suppressors

Readers

  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology