Design and Synthesis of New Breast Cancer Chemotherapeutic Agents
Abstract
This project is directed towards the design and synthesis of new drugs to treat breast cancer. Several naturally occurring substances have recently been discovered that have the same biological activity as the very important anticancer drug Taxol. We are using both computational and synthetic approaches to determine the parts of these very different compounds that are important for their biological activity. The determination of these 1,critical parts" could lead to the development of simpler structures that could be very powerful anticancer drugs. During the grant award period, we have prepared new structures based on the taxol-like substance epothilone. While the structures of the new compounds that we have prepared are very much like epothilone itself, we have not yet been able to prepare a simple structure with the same anticancer properties as taxol and epothilone.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2001
- Accession Number
- ADA392461
Entities
People
- Jeffrey D. Winkler
Organizations
- University of Pennsylvania