IGF-1, 1,25(OH)2 Vitamin D, and Prostate Cancer
Abstract
High circulating levels of insulin-like growth factor-i (IGF-l) or low levels of 1,25 (OH)2 vitamin D (1,25 (OH) 2D) are associated with increased risk of prostate cancer. This project examines whether specific dietary patterns are related to prostate cancer by influencing levels of IGF-1 and 1,25(OH)2D; specifically whether high energy and protein intakes increase IGF-l and high intakes of calcium, phosphorus, and animal protein decrease 1,25 (OH) 2D levels. The relationships between dietary factors and circulating 1,25 (OH) 2D were examined in 630 men using the Massachusetts Male Aging Study. None of the hypothesized nutrients correlated significantly with 1,25(OH)2D levels, suggesting that dietary modulation of vitamin D may not be a critical mechanism linking nutritional factors to prostate cancer. We are currently evaluating IGF-1 levels in the Health Professional Follow-Up Study database. After examining the relation between the dietary factors and IGF-l level, we will use these data to formulate a predicted IGF-1 score for men in the Health Professional Follow-Up Study based on their responses to a dietary questionnaire, and then examine the predicted impact of the combined effect of pertinent dietary factors in relation to prostate cancer risk Ultimately, our aim is to understand mechanisms underlying how specific dietary factors influence development of prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA392507
Entities
People
- Edward L. Giovannucci
Organizations
- Harvard T.H. Chan School of Public Health