Molecular Epidemiology of Breast Cancer: Establishment of an at Risk Cohort and Methods to Improve the Collection and Use of Risk Factor Data
Abstract
The objective of our research program was to develop a research infrastructure for studies defining molecular markers and their interaction with other factors as risk indicators for development of breast cancer among women with benign breast disease (BBD). We estimated the incidence of breast cancer development in African American and Caucasian women with biopsy-proven BBD and collected and archived in a specimen bank samples of benign breast disease lesions and breast cancer from women in this cohort. We also developed a culturally sensitive questionnaire for collecting breast cancer risk factor information. We constructed a cohort of women with BBD between 1981-1994 who were followed from 5-15 years and yielded 218 women who developed invasive breast cancer. This work built the foundation, in terms of a cohort, a specimen bank and a survey instrument for the conduct of molecular epidemiologic studies of breast cancer in & multi-ethnic population.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA392530
Entities
People
- Christine C. Johnson
Organizations
- Henry Ford Health