Instrumentation for Chemical Studies of Biomimetrics
Abstract
The research work for this proposal has proceeded extremely well and significant progress has been made. As outlined in the original proposal, the initiative features collaborative interactions among several core faculty in bioorganic and biophysical chemistry to share expertise, technology, and ideas. We are happy to report that collaborations among, not only these faculty', but also numerous other groups on campus has resulted from the acquisition of the equipment. Together, these faculty have brought fundamental studies of protein-nucleic acid and protein- protein interactions as well as interactions of proteins with prosthetic groups and ligands to bear on key structure-function questions with potential applications to biocatalysts, biomaterials, and biosensors. The original budget request listed five instruments to support chemical studies of biomimetics. The revised budget was pared down to three major instruments. After extensive evaluation and discussion among the co-P.I.s and other users, we concluded that the combined specifications of high resolution circular dichroism (CD) spectra and high signal-to-noise stopped- flow kinetic data were not available in a single instrument. We therefore purchased four instruments as described below. We also purchased an ultracentrifuge rotor for protein purification.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2001
- Accession Number
- ADA392602
Entities
People
- Mary Barkley
Organizations
- Case Western Reserve University