Molecular Mechanisms of Estrogen and Antiestrogen Resistance

Abstract

This is an Academic Award (Career Development Award). The purpose of this application is to free additional time for the Principal Investigator to "..appraise critically the state of the science in a particular aspect of breast cancer research and to forge new avenues of investigation. "The PI will apply new, state-of-the-art technologies to identify key endocrine-regulated molecular pathways to apoptosis / proliferation. By identifying key components of these pathways, we may be able to predict response to first-line and crossover antiestrogenic therapies, and/or provide novel therapeutic strategies for antiestrogen resistant tumors. We also will establish a SAGE database containing the molecular profile of MCF-7 cells and several variants.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2000
Accession Number
ADA393267

Entities

People

  • Robert Clarke

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Health Services
  • Medical Personnel
  • Peptide Growth Factors
  • Proteins

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology
  • Systems Analysis and Design