The Role of the Cell Surface Proteases Meprin A and B in Breast Cancer Progression

Abstract

Meprins are extracellular proteases that have been implicated in the progression of cancer from a nonmetatstratic to a metastatic phenotype. Current studies have indicated that meprins can cleave the extracellular matrix protein fibronectin, and denatured collagen (gelatin) in vitro. In addition, overexpression of meprins on cultured breast cancer cells increased their in vitro invasiveness through reconstituted basement membrane (Matrigel). This evidence indicates meprins may influence extravasation, intravasation and formation of tumors at secondary sites.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2001
Accession Number
ADA393343

Entities

People

  • Gail L. Matters

Organizations

  • Penn State College of Medicine

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Aspartic Acid
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Gastrointestinal Tract
  • Intestines
  • Liquid Chromatography
  • Molecular Biology
  • Neoplasms
  • Peptides
  • Pituitary And Hypothalamic Hormones And Analogues
  • Proteins

Fields of Study

  • Biology

Readers

  • Irregular Warfare and Special Operations Cyberspace Operations against Adversarial Threats.
  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).