A Multidisciplinary Approach to Generating Effective Therapeutics for Emerging Hantavirus

Abstract

The major goals of this project are to purify hantavirus proteins (Jonsson) for X-ray structure determination (Arnold). By defining the three-dimensional structures of the N and RDRP proteins of hantaviruses, our studies will afford a means to model drugs that specifically interfere with important stages of viral replication. Particularly, disrupting one or more functions of the RDRP is expected to result in effective disease treatment with little toxicity to host cells. In addition, our research will yield a high through-put in vitro assay for identification of new antiviral drugs. Together, these studies should lead toward effective therapeutic measures for controlling and treating hantaviral infections.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2001
Accession Number
ADA393345

Entities

People

  • Colleen B. Jonsson
  • Edward Arnold

Organizations

  • New Mexico State University

Tags

DTIC Thesaurus Topics

  • Acids
  • Amino Acids
  • Biochemistry
  • Chemical Synthesis
  • Chemistry
  • Escherichia Coli
  • Gel Electrophoresis
  • Infectious Diseases
  • Light Scattering
  • Materials
  • Molecular Biology
  • Molecular Weight
  • New Mexico
  • Nucleic Acids
  • Nucleotides
  • Organic Chemistry
  • Proteins

Readers

  • Oncology (Cancer Research).
  • Virology (or Medical Virology).