P53 Regulation of Uridine Phosphorylase Activity Pyrimidine Salvage Pathway and Their Effects on Breast Cancer Therapy

Abstract

This research project has been focused on the exploration of a new strategy to improve the therapeutic index of fluoropyrimidines. Based on the knowledge that uridine phosphorylase (Upase) has a key role in the cancer therapy because of its effects on the metabolism (activation) of fluoropyrimidines and on their biochemical modulators such as uridine, and our recent finding of p53 regulation on UPase expression, we concentrated our research on two main areas: 1) Elucidation of the regulation mechanism(s) of UPase expression; and 2) determination of the role of UPase in the metabolism of pyrimidines. The research achievements will help to improve the clinical management of breast cancer patients.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA393945

Entities

People

  • Deliang Cao
  • Giuseppe Pizzorno

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Blood
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chemotherapy
  • Culture Techniques
  • Gene Expression
  • Health Services
  • Neoplasms
  • Nucleotides
  • Proteins
  • Tumor Cell Line

Readers

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