Insulin and Breast Cancer Risk

Abstract

There is evidence suggesting that life-style factors play a significant role in breast cancer (BC) development. Insulin, which secretion is influenced by life-style factors, might represent the possible etiological linkage between lifestyle characteristics and BC. Insulin might act in the carcinogenetic process through mitogenic effect on breast epithelium. Furthermore, insulin modulates an additional proliferative and hormone-regulating factor which may be involved in the etiology of BC: the Insulin-like Growth Factor I (IGF-I). The investigators have proposed to test the hypothesis of the linkage between serum insulin and BC in an Italian prospective cohort study conducted to investigate the role of hormones and diet in the etiology of BC (the ORDET study).

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2001
Accession Number
ADA394074

Entities

People

  • Paola Muti

Organizations

  • University at Buffalo

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood
  • Blood Cells
  • Breast Cancer
  • Cardiovascular Diseases
  • Cell Membrane
  • Cells
  • Chemistry
  • Fatty Acids
  • Growth Factors
  • Materials
  • Neoplasms
  • New York
  • Papillomavirus Infections
  • Regression Analysis
  • Statistical Analysis

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