Cell Surface Regulation of Matrix Metalloproteinases in Breast Cancer Cells
Abstract
Metastasis is the major cause of death in breast cancer patients and is partly caused by the action of proteolytic enzymes that degrade extracellular matrix (ECM). We have focused on the gelatinases, MMP-2 and MMP-9, two ECM-degrading enzymes that are members of the matrix metalloproteinase (MMP) family of proteases. The gelatinases are associated with the surface of breast cancer cells. MMP-2 surface binding plays a role in activation by MMT1-MMP, a membrane-bound MMP that is also expressed in breast cancer. MMP-2 activation is mediated by the action of TIMP-2, a metalloproteinase inhibitor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA394082
Entities
People
- Rafael Fridman
Organizations
- Wayne State University