Neuronal Sodium Channels in Neurodegeneration and Neuroprotection

Abstract

HE PURPOSE OF THIS RESEARCH PROJECT IS TO STUDY THE ROLE OF NEURONAL SODIUM CHANNELS IN MECHANISMS OF NEURONAL INJURY, NEURODEGENERATION AND NEUROPROTECTION. The primary objective of this research project is to characterize the expression, and study the functional significance, of neuronal sodium channels during the process of injury and recovery. Also, the effects of sodium channel blockade (using antisense and channel blockers) on gene expression and neurodegeneration will be studied. The progress during our 2nd year of this project was significant, yielding several important and critical discoveries providing a greater understanding of the injury/neurodegeneration process, and the importance of sodium gated channels in brain trauma.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2001
Accession Number
ADA394087

Entities

People

  • Frank Tortella

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Body Weight
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cells
  • Cerebrovascular Disorders
  • Chemical Synthesis
  • Chemistry
  • Drug Abuse
  • Gene Expression
  • Neurodegeneration
  • Neuroprotective Drugs
  • Peripheral Nervous System
  • Seizures
  • Surgery

Fields of Study

  • Biology

Readers

  • Neuroscience